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LPS stimulation of macrophages results in abundant succinate production, which stabilizes Hypoxia-inducible factor 1 (HIF-1) and IL-1 an important downstream target (73)

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[DOI] [PMC free article] [PubMed] [Google Scholar] [87].Shefner R, Kleiner G, Turken A

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In addition, it has been shown to contribute to angiogenesis (a process of forming new blood vessels)